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For Immediate Release

Polymeric platform for drug-releasing coatings offered by Bayer MaterialScience LLC


Programmable elution from Baymedix™ CD can be customized to a wide range of active ingredients


April 7, 2010

Pittsburgh, April 7, 2010 — Bayer MaterialScience LLC recently introduced its Baymedix™ CD drug-releasing coating platform to the North American market. This technology was developed with an eye to the drug-eluting stent market, but collaborations are already underway with manufacturers of a variety of drug-releasing medical devices.

The key feature of the Baymedix™ CD family of coatings is its ability to be customized to achieve different release rates. This is accomplished by a careful balance of the hydrophobic and hydrophilic elements of the polymer matrix. The platform is widely tunable, allowing the target drug to be completely released in as little as a few hours, or up to several months. The tunability also means a range of active substances can be released, from small molecule drugs to biopharmaceuticals. Release kinetics are first-order with little or no burst effect.

Importantly, the mechanical properties of the coatings are suitable for many demanding applications. Baymedix™ CD coatings are both strong and flexible, allowing them to be used, for example, on expandable stents. The smooth, uniform appearance of the coatings, applied by spraying or dipping, is an additional benefit.

Although it can also be coated onto polymeric substrates, the coating has been engineered to give good adhesion to metals like stainless steel and nitinol. The process for coating a device involves a surface activation step, an additional surface modification step, and then application of the coating along with the drug. The surface modification allows a covalent bond between the substrate and the coating to be formed, giving excellent adhesion.

Baymedix™ CD's suitability for implantation has been demonstrated in part by 28-day and 90-day porcine coronary artery tests, where no adverse reactions were seen. Additional biocompatibility tests support the inertness of these coatings. They can be sterilized by gamma irradiation or ethylene oxide.

Bayer MaterialScience LLC is actively seeking customer collaborations to provide feedback on this technology. This product line is part of a major commitment by the company to provide value-added coatings solutions to medical device manufacturers.

Bayer MaterialScience LLC is one of the leading producers of polymers and high-performance plastics in North America and is part of the global Bayer MaterialScience business with nearly 15,100 employees at 30 sites around the world and 2008 sales of 9.7 billion euros. Business activities are focused on the manufacture of high-tech polymer materials and the development of innovative solutions for products used in many areas of daily life. The main segments served are the automotive, electrical and electronics, construction, medical, and sports and leisure industries.

For more information about Bayer MaterialScience LLC's coatings, adhesives or specialties, call 412-777-3983, e-mail naftainfo@bayerbms.com or visit www.bayermaterialsciencenafta.com.

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This website may contain forward-looking statements based on current assumptions and forecasts made by Bayer Group or subgroup management. Various known and unknown risks, uncertainties and other factors could lead to material differences between the actual future results, financial situation, development or performance of the company and the estimates given here. These factors include those discussed in Bayer's public reports which are available on the Bayer website at www.bayer.com. The company assumes no liability whatsoever to update these forward-looking statements or to conform them to future events or developments.


Media Contact(s)
Name: Sean Kelly
Phone: 412-777-5200
Company: Bayer MaterialScience
Email: sean.kelly@bayerbms.com








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